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基本信息:

姓名: 谢幸
职务: 浙江省女性生殖健康重点实验室主任
职称: 教授
学历: 硕士研究生
专业: 妇产科学
所属院系: 妇产科医院
研究方向: 妇科肿瘤
电话: 87061501-1001
信箱: xiex@zju.edu.cn
个人主页:

个人概况:

学术团体和社会兼职:谢幸,男,1955年7月出生,教授,主任医师,博士生导师。国家重点(培育)学科和浙江省重点学科-妇产科学学科带头人。浙江省有突出贡献中青年专家。现为浙江省女性生殖健康重点实验室主任、浙江省宫颈疾病诊治中心主任。现为中华医学会妇科肿瘤分会副主任委员、中华医学会妇产科学分会常委、中华预防医学会妇女保健学会常委、中国抗癌协会妇科肿瘤专业委员会委员、浙江省医师协会妇产科学分会会长、浙江省抗癌协会妇科肿瘤专业委员会主任委员、浙江医学会妇产科学分会主任委员、浙江省预防医学会妇幼保健院管理专业委员会主任委员。
学历和研究经历:1983年毕业于葡京国际娱乐平台网址(原浙江医科大学)。1988获葡京国际娱乐平台网址妇科肿瘤专业硕士学位,曾赴德国、美国等国留学。
学科专长:妇科肿瘤的临床和基础研究,具有丰富的实践经验,尤其在妇科肿瘤诊治方面有较深的研究和造诣。
研究方向:妇科肿瘤基础研究,包括卵巢癌与腹腔免疫缺陷及其机制、宫颈癌发生的免疫学和分子遗传学机制、妊娠滋养细胞疾病发病的分子遗传学机制等。
在研的主要项目:主持或参加国家和省厅研究课题50余项。
1.国家自然科学基金课题 (ID30973173),人乳头状瘤病毒特异性的细胞miRNA在调控E6/E7表达中的作用及其机制;(2009.1-2011.1);主持。
2. 国家自然科学基金课题(ID 30672229). 卵巢癌微环境诱导调节性树突状细胞的分化及其信号转导;(2007.1- 2009.1);主持。
3.国家自然科学基金课题(ID 30471811). 树突状细胞亚群漂移及肿瘤诱导细胞死亡的分子机理研究;(2005.1- 2007.1);主持。
4.浙江省科技厅基金(ID 2004C33053). HPV型别筛查方法的建立;(2004.1-2006.1);主持。
5.高等学校博士学科点专项科研基金 (ID 20030335086). 卵巢癌多药耐药研究;2004.1-2007.1);主持。
6. 浙江省科技厅基金(ID J30211). HPV疫苗宫颈癌防治中的作用及应用;(2002.1-2003.12);主持。
7.浙江省科技厅基金(ID J30119),脐血干细胞库及其在卵巢癌中的应用;(2001.1-2003.12);主持。
8.浙江省自然科学基金 (ID 3999116), IL-7和IL-2联合转染卵巢癌细胞的体外研究;(2000.1-2002.12);主持。
9.浙江省自然科学基金(ID 397461),IL-2受体基因在抗卵巢癌中的作用;(1999.1-2001.12);主持。
代表论文:已在国内外各种学术期刊发表论著300余篇,其中SCI收录期刊论文60余篇。
1.Shi YF, Xie X, Zhao CL, Ye DF, Lu SM, Hor JJ, Pao CC. Lack of mutation in tumour-suppressor gene p53 in gestational trophoblastic tumours. Br J Cancer 1996;73(10):1216-1219.
2.Stevenson AFG, Xie X, Kunstmann P. Cell culture of biopised endometrial after danazol/hormonal therapy: a study of growth features and fertility effects. Indian J Exper Biolo 2000; 38:1192-1200.
3.Ye D, Xie X, Lu W, Chen H, Cheng B. Growth inhibition of interleukin-2 receptor gene-tranduced peripheral blood lymphocytes on human ovarian cancer cells. Chin Med J (English) 2001; 114(3): 303-307.
4.Dong MY, Xie X, Wang ZP, He J, Zhou JH, Cheng Q. Impaired mixed lymphocyte reaction in intrahepatic cholestasis of pregnancy. Gynecol Obstet Invest 2002; 54(4):191-195.
5.Xie X, Lu WG, Ye DF, Chen HZ, Fu YF. The value of curettage in diagnosis of endometrial hyperplasia. Gynecol Oncol 2002;84 (1):135-139.
6.Chen HZ, Ye DF, Xie X, Chen B, Lu WG. VEGF, VEGFRs expressions and activated STATs in ovarian epithelial carcinoma. Gynecol Oncol 2004; 94(3):630-635.
7.Wang H, Xie X, Lu WG, Ye DF, Chen HZ, Li X, Cheng Q. Ovarian carcinoma cells inhibit T cell proliferation: suppression of IL-2 receptor beta and gamma expression and their JAK-STAT signaling pathway. Life Sci 2004; 74(14):1739-1749.
8.Xie X, Ye D, Chen H, Lu W, Cheng B, Zhong H. Interleukin-7 and suppression of local peritoneal immunity in ovarian carcinoma. Int J Gynaecol Obstet 2004; 85(2):151-158.
9.Xie X, Ye DF, Chen HZ Lu WG, Fu YF, Cheng B, Zhu H. Effect of interleukin-7 gene transaction into ovarian carcinoma cell line SKOV3 in vitro and in vivo. Gynecol Oncol 2004; 92(2):578-585.
10.Ye F, Chen HZ, Xie X, Ye DF, Lu WG, Ding ZM. Vascular endothelial growth factor (VEGF) and ovarian carcinoma cell supernatant activate signal transducers and activators of transcription (STATs) via VEGF receptor-2 (KDR) in human hemopoietic progenitor cells. Gynecol Oncol 2004; 94(1):125-133.
11.Zhang M, Lee AH, Binns CW, Xie X. Green tea consumption enhances survival of epithelial ovarian cancer. Int J Cancer 2004; 112(3):465-469.
12.Zhang M, Xie X, Lee AH, Binns CW. Sedentary behaviours and epithelial ovarian cancer. Cancer Cause Control 2004; 15:83-89.
13.Zhang M, Xie X, Lee AH, Binns CW. Soy and isoflavone intake are associated with reduced risk of ovarian cancer in Southeast China. Nutr Cancer 2004; 49(2):125-130.
14.Zhang M, Xie X, Lee AH, Binns CW. Prolonged lactation reduced ovarian cancer risk in Chinese women. Eur J Cancer Prev 2004; 13:499-502.
15.Chen HZ, Ye DF, Xie X, Lu W, Zhu C, Chen X. PTEN promoter methylation and protein expression in normal early placentas and hydatidiform moles. J Soc Gynecol Investig 2005;12:214-217.
16.Chen HZ, Ye DF, Xie X, Lu W, Zhu C, Chen X. Mismatch repair gene promoter methylation and expression in hydatidiform moles. Arch Gynecol Obstet 2005; 272(1):35-39.
17.Zhang M, Xie X, Lee AH, Binns CW, Holman CDJ. Body mass index in relation to ovarian cancer survival. Cancer Epidem Biomar 2005; 14(5):1307-1310.
18.Zhang M, Xie X, Holman CDJ. Body weight and body mass index and ovarian cancer risk: a case-control study in China. Gynecol Oncol 2005; 98(2):228-234.
19.Huang JP, Zhang M, Holman CDJ, Xie X. Dietary carotenoids and risk of breast cancer in Chinese women. Asia Pac J Clin Nutr 2007;16 suppl 1:437-442
20.Li X, Ye DF, Xie X, Chen HZ, Lu WG. Proportion of CD4+CD25+ regulatory T cells is increased in the patients with ovarian carcinoma. Cancer Invest 2005; 23:399-403.
21.Lu WG, Chen HZ, Ye F, Wang F, Xie X. VEGF induces phosphorylation of STAT3 through binding VEGFR2 in ovarian carcinoma cells in vitro. Eur J Gynecol Oncol 2006;27(4):363-369.
22.Ye F, Chen HZ, Xie X, Ye DF, Lu WG. Ovarian carcinoma cells effectively inhibit differentiation and maturation of dendritic cells derived from hematopoietic progenitor cells in vitro. Cancer Invest 2005; 23(5):379-385.
23.Zhang M, Holman CDJ, Huang JP, Xie X. Green tea and the prevention of breast cancer: a case-control study in southeast China. Carcinogenesis 2007;28(5):1074-1078
24.Zhou JH, Chen HZ, Ye F, Lu WG, Xie X. Fas-mediated pathway and apoptosis in normal cervix, cervical intraepithelial neoplasia and cervical squamous cancer. Oncol Rep 2006; 16(2):307-311.
25.Zhou JH; Ye F; Chen HZ; Zhou CY; Lu WG; Xie X. Altered expression of cellular membrane molecules of HLA-DR, HLA-G and CD99 in cervical intraepithelial neoplasias and invasive squamous cell carcinoma. Life Sci 2006; 78(22):2643-2649.
26.Mao, YY , Wan, XY , Lv, WG, Xie, X .Relapsed or refractory gestational trophoblastic neoplasia treated with the etoposide and cisplatin/etoposide, methotrexate, and actinomycin D (EP-EMA) regimen. Int J Gynecol Obstet 2007; 98 (1): 44-47
27.Wan, X ,Li, J, Xie, X , Lu, W .PTEN augments doxorubicin-induced apoptosis in PTEN-null Ishikawa cells. Int J Gynecol Cancer 2007; 17 (4): 808-812
28.Huang, JY, Ye, F ,Chen, HZ , Lu, WG , Xie, X. Amino acid substitution polymorphisms of the DNA repair gene MGMT and the susceptibility to cervical carcinoma. Carcinogenesis 2007;28 (6): 1314-1322
29.Li, X , Ye, F , Chen, HZ , Lu, WG , Wan, XY , Xie, X .Human ovarian carcinoma cells generate CD4(+) CD25(+) regulatory T cells from peripheral CD4(+)CD25(-) T cells through secreting TGF-beta. CANCER LETTERS 2007;253 (1): 144-153
30.Huang J ,Ye F ,Chen H , Lu W , Xie X .The nonsynonymous single nucleotide polymorphisms of DNA repair gene XRCC1 and susceptibility to the development of cervical carcinoma and high-risk human papillomavirus infection. Int J Gynecol Cancer 2007;17 (3): 668-675
31.Fu Y , Lu W , Zhou C , Xie X .Primary cervical choriocarcinoma: report of four cases and literature review. Int J Gynecol Cancer 2007;17(3): 715-719
32.Fu YF, Ye DF , Chen HZ, Lu WG , Ye F, Xie X .Weakened spindle checkpoint with reduced BubR1 expression in paclitaxel-resistant ovarian carcinoma cell line SKOV3-TR30.Gynecol Oncol 2007;105 (1): 66-73
33.Ying W ,Li Y , Zhou Y, Xie X .Cyst distortion: a new sonographic sign of peritoneal pseudocyst with regular morphology. Ultrasound in Obstetrics & Gynecology 2007 29 (2): 240-241
34.Zhang JP, Lu WG, Ye F, Chen HZ, Zhou CY, Xie X. Study on CXCR4/SDF-1 alpha axis in lymph node metastasis of cervical squamous cell carcinoma. Int J Gynecol Cancer 2007 17(2): 478-483
35.Chen H , Ye F, Zhang J, Lu W , Cheng Q ,Xie X.Loss of OPCML expression and the correlation with CpG island methylation and LOH in ovarian serous carcinoma. Eur J Gynecol Oncol 2007 28 (6): 464-467
36.Liu J , Ye F, Chen H , Lu W , Zhou C , Xie X .Expression of differentiation associated protein Hes1 and Hes5 in cervical squamous carcinoma and its precursors. Int J Gynecol Cancer 2007;17 (6): 1293-1299
37.Ye F, Chen H, Liang Z, Lu W, Cheng Q, Xie X. Establishment of a cervical cancer model via inoculating SiHa Cells into humanized severe combined immunodeficient mice. Eur J Gynaecol Oncol 2006; 27(6):566-572
38.Huang JY, Ye F, Chen HZ, Xing X. Amino acid substitution polymorphisms of the DNA repair gene MGMT and the susceptibility to cervical carcinoma. Carcinogenesis 2007; 28(6):1314-1322
39.Zhang M, Holman CD, Huang JP, Xie X. Green tea and the prevention of breast cancer: a case-control study in southeast China. Carcinogenesis 2007 ; 28(5):1074-1078
40.Li X,Ye F, Chen HZ, Xie X. Human ovarian carcinoma cells generate CD4(+)CD(25+)regulatory T cells from peripheral CD4(+)CD25(-) T cells through secreting TGF-beta. Cancer Letters 2007; 253(1):144-153
41.Lin K ,Ye D,Xie X .Protein expression levels of excision repair cross-complementation group 1 and xeroderma pigmentosum D correlate with response to platinum-based chemotherapy in the patients with advanced epithelial ovarian cancer. Inter J Gynecol Cancer 2008;18 (5): 1007-1012
42.Ye F ,Hu Y, Lu W , Zhou C,Xie X. Expression of leukaemia inhibitory factor in epithelial ovarian carcinoma: correlation with clinical characteristics. Histopathology 2008; 53 (2): 224-228
43.Ma YX , Ye F , Lu WG, Cheng Q, Chen HZ , Xie X. Correlation between soluble Fas level and apoptosis of T cells in ovarian carcinoma. European J of Obstetrics Gynecology and Reproductive Biology 2008;138 (2): 204-211
44.Zhang D ,Ding Z ,Qian J ,Xie X, Wang Y.Two rare cases of methotrexate-induced pneumonitis and pleurisy in patients with gestational trophoblastic neoplasms. European J of Gynecological Oncology 2008;29 (4): 390-392
45.Ye F , Zhang SF, Xie X, Lu WG.OPCML gene promoter methylation and gene expression in tumor and stroma cells of invasive cervical carcinoma. Cancer Inves 2008;26 (6): 569-574
46.Luo J, Qian JH, Yu JK , Zheng S , Xie X , Lu WG .Discovery of altered protein profiles in epithelial ovarian carcinogenesis by SELDI mass spectrometry. European J of Gynecological Oncology 2008;29 (3): 233-238
47.Lu WG,Ye F, Shen YM , Fu YF, Chen HZ , Wan XY, Xie X. EMA-CO chemotherapy for high-risk gestational trophoblastic neoplasia: a clinical analysis of 54 patients. Int J Gynecol Cancer 2008;18 (2): 357-362
48.Chen YX , Xu J, Lu WG , Xie X. Primary ovarian choriocarcinoma mimicking ectopic pregnancy managed with laparoscopy - case report . European J of Gynecological Oncology 2008; 29 (2): 174-176
49.Hong D,Ye F,Chen H, Lu W, Cheng Q, Hu Y, Xing X .Distribution of human papillomavirus genotypes in the patients with cervical carcinoma and its precursors in Zhejiang Province,China. International Journal of Gynecological Cancer 2008;18(1):104-109
50.Mao YY,Wan XY, Chen YX, Xing X.Evaluation of the accuracy of intraoperative gross examination for the surgical management of endometrial cancer. European J of Obstetrics Gynecology and Reproductive Biology 2008;141(2):179-182
51.Hong D,Ye F, Lu WG, Xing X.Methylation status of the long control region of HPV 16 in clinical cervical specimens. Molecular Medicine Reports 2008;1(4):555-560
52.Hong D, Lu W,Ye F, Hu Y, Xing X.Gene silencing of HPV16 E6/E7 induced by promoter-targeting siRNA in SiHa cells. British J of Cancer 2009,101(10):1798-1804
53.Chen W,Zhang X, Molijn A, Jenkins D, Shi JF, Quint W, Schmidt JE, Wang P,Liu YL, Li LK, Xing X et al. Human papillomavirus type-distribution in cervical cancer in China: the importance of HPV 16 and 18.Cancer Causes & Control 2009;20(9):1705-1713
54.Wang XY, Pan ZM, Chen XD, Xie X. Accuracy of tumor grade by preoperative curettage and associated clinicopathologic factors in clinical stage I endometriod adenocarcinoma. Chinese Medical Journal 2009; 122(16):1843-1846
55.Tian QF, Lu WG,Chen HZ, Ye F, Xing X. The Nonsynonymous Single-Nucleotide Polymorphisms in Codon 31 of p21 Gene and the Susceptibility to cervical cancer in Chinese women. International J of Gynecological Cancer.2009, 19(6):1011-1014
56.Cheng XD, Lu WG,Ye F,Wan XY, Xie X.The association of XRCC1 gene single nucleotide polymorphisms with response to neoadjuvant chemotherapy in locally advanced cervical carcinoma. J of Experimental &Clinincal Cancer Research.2009; 28:91
57.Hu Y, Ye F,Lu WG,Xing X. HPV16 E6-induced and E6AP-dependent inhibition of the transcriptional coactivator hADA3 in human cervical carcinoma cells. Cancer Investigation 2009; 27(3):298-306
58.Chen LL, Ye F, Lu W, Hong D, Wan X, Xing X. Evaluation of immune inhibitory cytokine profiles in epithelial ovarian carcinoma. J of Obstetrics and Gynecology Research. 2009;35(2):212-218
59.Zhao XF, Ye F, Chen LL, Lu W, Xing X. Human epithelial ovarian carcinoma cell-derived cytokines cooperatively induce activated CD4+CD25-CD45RA+naive T cells to express forkhead box protein 3 and exhibit suppressive ability in vitro. Cancer Science 2009; 100(11):2143-2151
60.Cheng B, Lu W, Xiaoyun W, YaXia C, Xie X. Extra-abdominal metastases from epithelial ovarian carcinoma: an analysis of 20 cases. International J of Gynecological Cancer 2009; 19(4):611-614
61.Cheng B, Wan XY, Qian X, Lv W, Xing X. Results of conservative surgery for recurrent borderline ovarian tumors. European J of Gynaecological oncology 2009; 112(1):199-204
62.Chen LL,Ye F, Xing X. Ovarian carcinoma cells influence differentiation of Lin-CD45RA-dendritic cell precursors into two mature subtypes in vitro. Gynocologic Oncology 2009;112(1):199-204
63. Zhang M, Huang J, Xie X, Holman CD. Dietary intakes of mushrooms and green tea combine to reduce the risk of breast cancer in Chinese women.Int J Cancer . 2009;15;124(6):1404-8.
64.Chen Y, Lu H,Wan WY,Xie X. Factors associated with postive margins in patients with cervical intraepithelial neoplasia grade and postcinization management. Int J Gynaecol Obstet, 2009;107(2):107-10
65.Wang X, Lu W, Zhu C,Ye F,Xie X. Adenoid cystic carcinoma of Bartholin’s gland with lung metastasis:a case report. Eur J Gynecol Oncol. 2009;30(3):317-20
66.Li Y, Ye F,Hu Y, L v W, Xie X. Identification of suitable reference genes for gene expression studies of human serous ovarian cancer by real-time PCR. Anal Biochem. 2009; 394(1):110-6
67.Chen H, Chen X, Ye F, Lu W, Xie X. Symmetric devision and expression of its regulatory gene Numb in human cervical squamous carcinoma cells. Pathobiology. 2009;76(3):149-54
荣誉和奖项: 获“浙江省优秀院长”称号,澳大利亚西澳大学“Raine杰出访问教授”。
作为负责人获部省级科技成果奖6项和国家发明专利1项。
1、教育部提名国家科技进步二等奖(2004年):白介素-2和白介素-7基因转染卵巢癌细胞的体外研究。
2、教育部提名国家科技进步一等奖(2005年):上皮性卵巢癌腹腔局部免疫缺陷机制的研究。
3、浙江省科技厅2006、2008年科学技术二等奖。
主编或参编专著和教材:担任人民卫生出版社国家规划教材《妇产科学》专升本教材主编、5年制教材副主编、长学制教材编者。并担任《International Journal of Biomedical Science》、《中华医学杂志(英文版)》、《中华医学杂志》、《中华妇产科杂志》、《中国实用妇科与产科杂志》、《现代妇产科进展》、《实用妇产科杂志》、《葡京娱乐学报(医学报)》、《浙江医学》、《实用肿瘤杂志》和《国际妇产科杂志》等国内外杂志的副主编、常务编委和编委,是《Carcinogenesis》、《Cancer Letters》、《Gynecol Oncol》和《Int J Gynecol Cancer》等国际著名SCI收录期刊的审稿专家。

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